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2. Materials and Methods {#sec2-nutrients-08-00229}
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2.1. Study Population {#sec2dot1-nutrients-08-00229}
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This was a prospective and controlled clinical trial. The study was conducted in accordance with the Helsinki Declaration, and the protocol was approved by the Institutional Ethics Committee of the Instituto Mexicano del Seguro Social (SSA/IMSS/PROTOCOL/13/02/0709). Male and female patients aged 18–60 years with type 2 diabetes mellitus for at least two years, glycated hemoglobin (HbA~1c~) \<8% and inadequate glycemic control \[[@B31-nutrients-08-00229]\] were included. The following exclusion criteria were applied: pregnancy; history of chronic diseases (such as cancer, cardiovascular diseases, cerebrovascular diseases, metabolic diseases, thyroid disease, and chronic gastritis) or other disease treated with drugs that might interfere with glucose metabolism or increase insulin resistance; history of acute illness; consumption of drugs that might alter glucose metabolism; history of coronary disease or acute myocardial infarction in the preceding six months; and use of weight loss drugs. Patients who were included in the study signed an informed consent form. In all cases, the patients were treated for the following three months with a commercial weight loss diet with the following nutritional characteristics: 60% carbohydrate (white bread), 10% protein (casein), 20% fat (vegetable), and a high fibre content (whole grains and other fruits and vegetables). All of the patients were instructed to eat between 1650--1850 kcal/day, to have three meals per day, and to drink

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